Exosomes

Exosomes are  released from the cell when multi vesicular bodies fuse with the plasma membrane . Exosomes have specialized functions and play a key role in processes such as coagulation, intercellular signalling, and waste management. They are being recognized as potential therapeutics as they have the ability to elicit potent cellular responses in vitro and in vivo. Compared with biomarkers identified in conventional specimens such as serum or urine, exosomal biomarkers provide the highest amount of sensitivity and specificity, which can be attributed to their excellent stability. The molecular constituents of exosomes, especially exosomal proteins and microRNAs (miRNAs), are promising as biomarkers in clinical diagnosis.

 

  • Exosomes and diagnosis of diseases like prion diseases, Epstein–Barr virus (EBV), kidney-related diseases etc.
  • Exosomal biomarkers for monitoring immunological rejection of tissue grafts.
  • Circulating Exosomes as new biomarkers for neurodegenerative disease or brain injury diagnosis.
  • Exosome-based approaches for diagnosis of cancers like: Colorectal Cancer and gastrointestinal cancer.
  • Exosomal microRNAs as biomarkers.
  • Exosomes and nanotheranostics.

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