Saad M Alshahrani
Prince Sattam Bin Abdulaziz University, Saudi Arabia
Title: Anticancer efï¬ cacy of self-nanoemulsifying drug delivery system of sunitinib malate
Biography
Biography: Saad M Alshahrani
Abstract
Sunitinib malate (SM) is reported as a weakly soluble drug in water due to its poor dissolution rate and oral bioavailability. Hence, in the current study, various “self-nanoemulsifying drug delivery systems (SNEDDS)” of SM were prepared, characterized and evaluated for the enhancement of its in vitro dissolution rate and anticancer effi cacy. On the basis of solubilization potential of SM in various excipients, “Lauroglycol-90 (oil), Triton-X100 (surfactant) and Transcutol-P (cosurfactant)” were selected for the preparation of SM SNEDDS. SM-loaded SNEDDS were developed by spontaneous emulsifi cation method, characterized and evaluated for “thermodynamic stability, self-nanoemulsifi cation effi ciency, droplet size, polydispersity index (PDI), zeta potential (ZP), surface morphology, refractive index (RI), the percent of transmittance (% T) and drug release profi le.” In vitro dissolution rate of SM was signifi cantly enhanced from an optimized SNEDDS in comparison with SM suspension. Th e optimized SNEDDS of SM with droplet size of 42.3 nm, PDI value of 0.174, ZP value of −36.4 mV, RI value of 1.339% T value of 97.3%, and drug release profi le of 95.4% (aft er 24 h via dialysis membrane) was selected for in vitro anticancer effi cacy in human colon cancer cells (HT-29) by MTT assay. MTT assay indicated signifi cant anticancer effi cacy of optimized SM SNEDDS against HT-29 cells in comparison with free SM. Th e results of this study showed the great potential of SNEDDS in the enhancement of in vitro dissolution rate and anticancer effi cacy of poorly soluble drug such as SM.